Article Sidebar
Published:
Feb 18, 2016Keywords:
Article Details
Copyright: Creative Commons Attribution CC.
This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.
Main Article Content
Antioxidantactivity of polyphenols from Toona sinensis roem seeds and the inhibition of aldose reductase
Abstract
Background: The seeds of Toona sinensis (Juss.) M. Roem (T. sinensis) have long been used in Traditional Chinese Medicine for the treatment of diabetes mellitus (DM) and its complications. The aim of this study was to investigate the antioxidant activity of different polyphenols fractions from Toona sinensis Roem (T. sinensis) seeds (PTSS) and the inhibition of aldose reductase (AR).
Methods: Macroporous resin was used to purify PTSS, and the antioxidant activities were evaluated with total antioxidant capacity and free-radical scavenging. AR inhibitory activities were investigated by employing various established systems.
Results: The polyphenol eluted by 60% alcohol (PTSS3) exhibit the highest antioxidant activity and AR inhibition, with an r value of 0.9924 ± 0.0066 in correlation analysis. The inhibition mechanism of PTSS3 on AR is uncompetitive inhibition.
Conclusion: This research demonstrates that PTSS offers potential for intervening diabetes mellitus and its complications.
Key words: Toona sinensis seeds, polyphenol, antioxidization, aldose reductase, diabetes mellitus
