Effets des extraits totaux aqueux de mallotus oppositifolium et de euphorbia hirta (euphorbiaceae) sur l’activite contractile intestinale du rat

Abstract

Effects of total aqueous extracts of Mallotus oppositifolium and Euphorbia hirta (Euphorbiaceae) on intestinal contractile activity of the rat. - The contractile activity of the total aqueous extract of Mallotus oppositifolium (Mo) and Euphorbia hirta (Eh) leaves was investigated. Mo extracts (1.32 mg/mL) demonstrated inhibiting effect on the stimulation of rat ileal contractions by acetylcholine (-9 mm) and potassium chloride (-7 mm). Administrated before the magnesium sulfate (6 g/kg), Mo extracts reduce the faeces quantity (- 11g, p<1 %). Eh activated the stimulation of rat ileal contractions by acetylcholine (+148 %) and potassium chloride (+381 %). Administrated
before the magnesium sulfate, the Eh aqueous extract reduced the quantity of faeces (-12 g, p<5 %). The results suggest that on the contractile activity of the rat intestine, total aqueous extracts of Mallotus oppositifolium could have antispasmodic effect, while Euphorbia hirta extracts could have
spasmogenic effect in vitro and antidiarrhoeic effects in vivo