Outcome of biopsy proven minimal change disease (MCD) in children

Abstract

Background and Objectives: MCD is the most common histological sub-type of nephrotic syndrome with variable clinical course in children. There are limited studies in literature on the outcome of biopsy proven MCD. The objective was to look at the treatment response and outcome of patients with MCD treated at a tertiary care paediatric hospital.
Materials and Methodology: The study was conducted from July 2009 to September 2012, at the department of paediatrics, SVPPGIP & SCB Medical College, Cuttack, Orissa, India. All nephrotic children aged 6 months- 14 years, with biopsy proven MCD were included in the study. The treatment protocol was followed as per the ISPN guidelines. Their demographic data, drug response pattern and treatment outcome were analyzed.
Results and Discussion: Of the 151 renal biopsies conducted in nephrotic patients, 49(32.4%) children had MCD. SRNS was most common clinical course 23 (46.94%) and most of the children responded to oral Cyclophosphamide 31 (63%). At the last follow up, 37(75.5%) children had IFRNS.
Conclusion: In our study, all cases of MCD responded to therapy and at the end of 1 year follow up, only 24% children had FRNS. This showed that MCD has better chance of achieving remission and outcome.

Keywords: MCD, children, renal biopsy, nephrotic syndrome