Article Sidebar
Keywords:
Diabetes mellitus Egypt HCV infection Nephropathy Neuropahty Retinopathy
Article Details
Issue
Section
Articles
Copyright belongs to The Arab Society of Nephrology and Renal Transplantation (ASNRT)
Main Article Content
Nephropathy and Neuropathy in Diabetic Patients with Chronic Hepatitis C Virus Infection
Abstract
Introduction: Several reports described an association between type 2 diabetes mellitus (DM) and chronic hepatitis C virus (HCV) infection. Chronic HCV infection is prevalent in Egypt. The present work aimed to evaluate the prevalence of proteinuria and neuropathy among diabetic patients with and without chronic HCV infection
Methods: A total of 70 diabetic patients were recruited from patients that attended the outpatient clinic of Mansoura Specialized Medical University Hospital. They were evaluated for diabetic retinopathy, peripheral neuropathy, autonomic neuropathy, high blood pressure, urinary albumin excretion (UAE), serum creatinine, lipid profile and assay of HCV-RNA.
Results: The prevalence of HCV infection among this group of diabetic patients was 35.7% compared to 10% in a matched control group (P< 0.05). Diabetic patients with chronic HCV infection (n=45) and diabetic patients without HCV infection (n=25) had no significant differences in diabetes type, diabetes duration, prevalence of hypertension, level of glycosylated hemoglobin or prevalence of diabetic retinopathy. The prevalence of macroalbuminuria, peripheral neuropathy and autonomic neuropahty was higher among diabetic patients with chronic HCV infection (P < 0.05). Also, diabetic patients with chronic HCV infection had higher mean arterial pressure, higher serum creatinine, higher triglyceride and cholesterol levels, and higher UAE (P < 0.05).
Conclusion: A high prevalence of HCV infection is observed among this group of Egyptian diabetic patients, and it was associated with higher rates of nephropathy and peripheral neuropathy compared to diabetic patients without HCV infection.
Key words: Diabetes mellitus; Egypt; HCV infection; Nephropathy; Neuropahty; Retinopathy
Methods: A total of 70 diabetic patients were recruited from patients that attended the outpatient clinic of Mansoura Specialized Medical University Hospital. They were evaluated for diabetic retinopathy, peripheral neuropathy, autonomic neuropathy, high blood pressure, urinary albumin excretion (UAE), serum creatinine, lipid profile and assay of HCV-RNA.
Results: The prevalence of HCV infection among this group of diabetic patients was 35.7% compared to 10% in a matched control group (P< 0.05). Diabetic patients with chronic HCV infection (n=45) and diabetic patients without HCV infection (n=25) had no significant differences in diabetes type, diabetes duration, prevalence of hypertension, level of glycosylated hemoglobin or prevalence of diabetic retinopathy. The prevalence of macroalbuminuria, peripheral neuropathy and autonomic neuropahty was higher among diabetic patients with chronic HCV infection (P < 0.05). Also, diabetic patients with chronic HCV infection had higher mean arterial pressure, higher serum creatinine, higher triglyceride and cholesterol levels, and higher UAE (P < 0.05).
Conclusion: A high prevalence of HCV infection is observed among this group of Egyptian diabetic patients, and it was associated with higher rates of nephropathy and peripheral neuropathy compared to diabetic patients without HCV infection.
Key words: Diabetes mellitus; Egypt; HCV infection; Nephropathy; Neuropahty; Retinopathy
