Glioma genetic susceptibility and survival analysis in the east Algerian population

Abstract

Background:
Genome-wide association studies (GWASs) have provided evidence for a polygenic basis of susceptibility to gliomas. The knowledge about these tumors remain very limited in Algeria. We aimed to investigate whether risk alleles identified by the GWASs were correlated with the glioma risk and the survival of patients in an Algerian cohort.
Methods:
We performed a case-control study on a cohort from east Algeria. We genotyped 17 polymorphisms identified by GWAS on the Sequenom MassARRAY platform. Fisher’s Exact test was used to analyze the association between risk variants and glioma risk and Kaplan-Meier method for survival analysis.
Results:
We have found a negative association between the analyzed SNPs and glioma susceptibility. Even if not confirmed, our results revealed four interesting SNPs in our population: One variant (rs2736100, 5p15.33, TERT) has shown a protective effect (OR = 0.21; 95%CI [0.06-0.64], p = 0.006) and three were identified as prognosis factor, i.e. rs12076373, rs3751667 and rs10852606.
Conclusion:
The genetic composition of the Algerian population may therefore harbor specificities relative to the susceptibility to glioma and survival of patients not yet discovered.