Primary cerebellar glioblastoma multiforme with uncharacteristic clinical and imaging features

Abstract

Introduction Cerebellarglioblastomamultiforme (GBM) is a very uncommon adult lesion. We present a case of cerebellar GBM and review their clinical, imaging and pathological features.
Case presentation We report the case of a 30 year-old Kenyan femalewith progressive headache and coordination deficits. A neurologic examination revealed the presence of cerebellar signs. Computed tomography (CT) demonstrated a well circumscribed, hemorrhagic lesion in the posterior fossa with minimalperilesionaloedemaand mild enhancement with contrast. On magnetic resonance imaging (MRI) the mass was hyperintense on T1-weighted, hypointense on T2-wieghted with minimal adjacent edema, showed blooming on gradient sequence and no restriction with diffusion. The mass had mild enhancement with gadolinium contrast. Suboccipitalcraniotomy was carried with pathologic examination revealing a highly cellular tumor with marked nuclear atypia, numerous mitoses and areas of necrosis.
Conclusions We report an unusual case of cerebellargliobastoma with atypical imaging findings. Cerebellarglioblastoma multiforme should be considered in the differential diagnosis of a cerebellar mass lesion.

Key words: Cerebellum, Glioblastoma, Posterior fossa