Effect of vitamin A on infertility induced by aluminum chloride in male albino mice

Abstract

Aims: The present study was designed to investigate the reproductive toxicity of Aluminum chloride (AlCl₃), and the potential protective role of vitamin A in adult male mice.

Methods: Twenty-one adult male albino mice were divided into three equal groups, the first group injected with distilled water, the second group injected with AlCl₃ (120 mg/kg BW) daily for 10 days. The third group was also injected with AlCl₃ (120 mg/kg BW) for 10 days, then injected with vitamin A (40 mg/kg) for another 10 days. All doses were given once daily via intraperitoneal injection.

Results: The results showed that AlCl₃ cause significant decrease in body weight, sperm motility, and sperm count, while it led to a significant increase in the number of abnormal sperm morphology. AlCl₃ caused apparent alterations in the histological structure of the testes. While treatment with vitamin A showed a protective effect on the damage caused by AlCl₃, on body weight, sperm parameters, and histoarchitecture of mice testes in comparison with AlCl₃ treated mice.

Conclusion: This study affords evidence for the protective role of vitamin A in ameliorating testicular toxicity caused by AlCl₃.