Determination of Some Haemostatic Parameters and Anthropometric Indices in Cervical Cancer Patients in Port Harcourt.

Abstract

Introduction: Cervical cancer is the second common female malignant tumor worldwide that seriously threatens female’s health. This study was aimed at determination of some haemostatic parameters and some anthropometric indices in cervical cancer subjects in Port Harcourt. This study was a case control study. There were two groups: Group A served as a test group, women that are histologically confirmed positive for cervical cancer, while Group B served as a negative control, women that were histologically confirmed negative for cervical cancer.

Materials and Methods: A total of 40 participants (20 histologically confirmed cervical cancer positive subjects and 20 histologically confirmed cervical cancer negative subjects) within the age of 40-70 years were recruited for this study. The demography and informed consent of the study subjects was obtained with the use of a well-structured questionnaire. Four milliliters (4mls) of blood sample were collected using vacutainers from each participant. Weight was recorded with the use of a mechanical scale; height was taken using stadiometer and body mass index (BMI) was calculated. Von Willebrand Factor (vWF), thrombomodulin, FVIII, Tissue plasminogen activator and D-dimer were analysed using ELISA technique. Prothrombin time (PT) and activated partial thromboplastin time (APTT) were analyzed using the manual method, and fibrinogen was analyzed using the coagulation method. The graph pad prism version 8.0.2.263 was used for data analysis. P<0.05 was considered significant. Results were presented as mean ± standard deviation (х±SD) in Tables and Figures.

Results: A statistically significant increase in the mean prothrombin time (PT) (p=0.0002) and APTT (p=0.0156) was observed among cervical cancer subjects when compared with the control subjects across all age brackets. There was also a significant increase in thrombomodulin (p<0.0001), tissue plasminogen activator (tPA) (p<0.0001), vWF (p<0.0001), FVIII (p<0.0001), and D- dimer (p<0.0001), in cervical cancer patients when compared with the controls.

Conclusion: This study concludes that there are coagulation and fibrinolytic derangements in subjects with cervical carcinoma.