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Association of Lewis blood group with Helicobacter pylori Infection amongst Undergraduates of Rivers State University, Port Harcourt, Nigeria.
Abstract
Aim: The study aims to determine the association of the Lewis blood group with Helicobacter pylori infection among undergraduates of Rivers State University, Port Harcourt, Nigeria.
Method: This cross-sectional study was aimed to elucidate the association between the Lewis blood group and Helicobacter pylori and was carried out among hundred (100) male and female undergraduates of Rivers State University recruited randomly from different ethnic groups in Nigeria. All samples were analysed at the haematology laboratory of Nimi Briggs Hospital, Rivers State University, between 25th and 28th October 2023. Using the Rapid Diagnostic Test Kit, the tube method was used for Lewis blood grouping and serology for the Helicobacter pylori infection. Blood samples were collected randomly based on convenient sampling from a total of 100 volunteers (aged 16 to 30 years).
Results: Statistical analysis was done using simple percentage calculation and Graph Pad Prism version 8 Statistical Package to determine odds ratios, relative risk, and likelihood ratios. Results are presented in Tables. The prevalence rate of Lea antigen in the total population is 81% (with a frequency of 29 (35.8%) in males and a frequency of 52 (64.2%) in females, while that of Leb antigen is 65% and with a frequency of 25 (38.5) in males and frequency of 40(61.5) in females. The Lewis antigen is more prevalent in females than males. The prevalence of Helicobacter pylori in the total population is 10%. Odd ratios show no association of Lewis antigens a and b with the prevalence of Helicobacter pylori infection.
Conclusion: From odd ratios, no risk of being infected with Helicobacter pylori can be associated with the presence of Lewis antigens a and b, as seen in the study. Helicobacter pylori infection has a percentage distribution of 10% in the total population, with a percentage distribution of 20% males and 80% females.
