Anti-infective and wound healing properties of Flabellaria paniculata

Abstract

The methanol leaf extract of Flabellaria paniculala was studied for its potency on normal wounds and infected wounds in rats. Wounds were inflicted on Wistar rats using excision model. Local infection was introduced into rat abdominal wounds using a 108 bacteria/ml inoculum. Two groups of infection were used: Staphylococcus aureus Pseudomonas aeruginosa . Rate of wound healing was assessed by contraction and p of epithelisation. Crude extract of F. paniculala demonstrated sic wound contraction and decrease in epithelisation period (p <0.05). On day 14, extract achieved 100% wound contraction in non-infected and Staphylococcus aureus while 100% wound contraction was recorded in Pseudomonas aeruginosa group on day 18. This drug is anti-infective as well as wound healing agent thus justifying the local uses of the plant for the treatment of skin diseases and sores.