Anti-inflammatory and analgesic activities of leaf extracts of Landolphia Owariensis

Abstract

The aqueous, methanol and chloroform extracts of Landolphia owariensis leaves (AELO, MELO & CELO respectively) was
investigated for anti-inflammatory and analgesic activities. All the extracts (100mg/kg each) were found to significantly (P<0.05)
inhibit paw edema induced by carrageenan in rats and the nociception induced by Tail immersion in hot water (50.0 ± 1.00C) and
acetic acid. The methanol extract produced the highest paw edema inhibition while in thermally induced nociception both the MELO
and CELO show high and comparable analgesic activity with acetylsalicylic acid (150mg/kg). However in chemically induced pain
(acetic acid) MELO produced the highest and comparable analgesic activity to acetylsalicylic acid (150mg/kg). We therefore
conclude, that apart from the folklore uses of L. Owariensis leaves as antimalarial agents, the various extracts of the plant also
possess anti-inflammatory and analgesic activities. Phytochemical analysis showed that the methanollic extract of L. owerensis
contain some secondary metabolites namely: alkaloids and some polyphenolic compounds. Also, this extract exhibits some antioxidative
activities