Effect of T. arjuna stem bark extract on histopathology of liver, kidney and pancreas of alloxan-induced diabetic rats

Abstract

The present study examined the effect of ethanolic extract (250 and 500 mg/kg body weight) of Terminalia arjuna stem bark in alloxan - induced diabetic rats for 30 days, and its histopathological study was investigated in the liver, kidney and pancreatic tissues sections. Pathological lesions were evoked in cells of diabetic rats. The extract improve the liver, kidney and pancreas function and reduce lesions associated with diabetic state in alloxan induced rats. The effect of oral administration of T. arjuna at a dose of 500 mg / kg body weight was more efficacy than the 250 mg/kg body weight. The results indicate the extract exhibit the protective effect on tissues, and proves its potentials as an antidiabetic agent. (Afr. J. Biomed. Res. 9: 189 – 197)

Keywords: Teminalia arjuna, histopathology, β- cell, lesions, alloxan