Effect of subchronic administration of ethanolic stembark extract of Mammea Africana sabine on haematological and biochemical parameters of rats

Abstract

The effect of subchronic administration of ethanolic stembark extract of
Mammea africana (30 – 90mg/kg) on haematological and biochemical
parameters of rats was studied. Significant decreases in activities of serum
alkaline phosphatase (ALP), Aspartate aminotransferase (AST) and
Alanine aminotransferase (ALT) as well as decreases in the levels of serum
total protein and albumin were observed in the extract treated rats
compared to control. White Blood Cell counts of the extract treated rats
also decreased significantly while other haematogical parameters were
unaffected. Thus, the extract has a slight toxicity at the doses studied.
(Afr. J. Biomed. Res. 9:129 - 132 , May 2006)

Keywords: Mammea africana, alkaline phosphatase, aminotransferase, haemotology.