Assessment Of Vitamin D Deficiency and Dyslipidemia in Obese Patients

Abstract

Background: The three main methods of obtaining vitamin D are through diet, sun exposure, and supplements. The most common type is formed by the skin after exposure to UVB rays. Vitamin D is thought to work more like a prohormone or multifunctional hormone. Calcitriol enters the enterocyte by the genomic route and binds to VDR. This generates a complex that attaches to particular DNA sequences in target genes known as vitamin D responsive elements (VDREs) and forms a heterodimer with the nuclear receptor known as retinoid X receptor (RXR), which is activated by retinoic acid. One alternative pathway for vitamin D activation, at least in keratinocytes, has been identified as the 20-hydroxylation of vitamin D, which is catalyzed by the side-chain cleavage enzyme CYP11A1, which is required for steroidogenesis.

Martial and Methods: Between December 2022 and May 2023, the following groups were studied. control group conducted among the obese population (100) participants, 50% of them were set as case group contained obese, and 50% were healthy subjects set as a control group, they were attended to patient Baghdad Medical City Teaching Hospital / Department of Medicine Both groups gave permission for enrolling in the study, which pre-approved by the ethical committee of1Clinical Communicable Diseases Research Unit /College of Medicine/University of Baghdad. Fasting blood samples withdrawn from each participant in a plane container in order to form serum, this collected later and preserved at -20 Co for later analysis process which conducted at bioMerieux-USA. Body mass index (BMI) calculated from weight and height of subjects, analytical parameters, vitamin D was assessed by VIDAS device depend on techniques of enzyme-linked fluorescence assay (ELFA) technique, while lipid profile was measured by means of Mindray.

Results: In this work we collected, one hundred (100) patients, included 67 % females and 33% male follow up their mean ± SD of age (44.18±18.34) years and body mass index 33.87+3.93 kg/m2 (figure 1). and 33% male follow up their mean ± SD of age (44.18±18.34) years and body mass index 33.87+3.93 kg/m2 (Figure 1). 

Conclusion: On the basis of our results, we can conclude that ow vitamin D level was found among obese people even though they were under treatment for dyslipidemia. suggested that vitamin D status should be checked regularly and supplementary doses should be administered in order to diminish harm that obese subjects could be subjected to in the current situation or in the in the coming future.