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“Synthesis Of 3, 4-Dihydropyrimidin-2(1H)-Ones Catalyse By Trimethylsilyl Trifluoromethanesulfonate On Silica Gel”


Shrikrishna G More
Mahesh P More
Parimeeta Chanchani

Abstract

A successful one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using Trimethylsilyl Trifluoromethanesulfonate on Silica gel as an inexpensive and readily available reagent through Biginelli condensation reaction of variable aldehydes, β-keto ester and urea/thiourea is described. Outstanding yields, short reaction times, recovery and reuse of catalyst and simple work-up are some attractive features of this protocol.


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eISSN: 1119-5096
print ISSN: 1119-5096