Main Article Content
“Synthesis Of 3, 4-Dihydropyrimidin-2(1H)-Ones Catalyse By Trimethylsilyl Trifluoromethanesulfonate On Silica Gel”
Abstract
A successful one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using Trimethylsilyl Trifluoromethanesulfonate on Silica gel as an inexpensive and readily available reagent through Biginelli condensation reaction of variable aldehydes, β-keto ester and urea/thiourea is described. Outstanding yields, short reaction times, recovery and reuse of catalyst and simple work-up are some attractive features of this protocol.