“Mg(HSO4).SiO2 Promoted Amidation Of Carboxylic Acid Under Microwave Irradiation”

Abstract

A new method for the direct synthesis of amides from carboxylic acids under microwave irradiation is described using magnesium hydrogen sulfate supported on silica as a low-cost and readily available catalyst. This methodology is particularly useful for the direct synthesis of secondary amides from carboxylic acid. Synthesis of amides using this technique is an economical, high yielding methodology with simple isolation process. This methodology tolerated most of the functional group and can be applicable at late stage amidation.