Study of clinicopathological features in perimenopausal women with abnormal uterine bleeding (M).

Abstract

Background: Abnormal uterine bleeding (AUB) is the most common health issue in women, defined as any bleeding pattern that differs in frequency, duration, and amount. AUB(M) is when the cause is due to malignancy or hyperplasia. Endometrial sampling and its histopathological examination is the first-line test in patients presenting with AUB(M). The aim of this study was to analyse the histopathological patterns of endometrium in women with AUB(M) and to find the predominant histopathologic pattern in perimenopausal women with AUB. Methods: The cross-sectional study was conducted at the JSS Medical College , mysore, from November 2019 to June 2021. Endometrial biopsies of patients with AUB(M), in whom other causes were ruled out, were included in this study. Results: Our analysis showed that maximum women were in the age group of 41 to 45 years (38.6%) with Heavy menstrual bleeding, being the most common clinical presentation (72.9%). 75.7% of the women on whom the Ultrasound scan was done, showed Endometrial thickness >12mm. Non-atypical Endometrial hyperplasia (50%) was the most common type of endometrial hyperplasia diagnosed on histopathology, followed by proliferative change(30%). Histopathological findings also included 1 case of endometrial adenocarcinoma. Conclusion: Although a regular cyclical pattern is observed commonly, endometrial sampling should be considered in the peri menopausal age groups wherein the incidence of endometrial hyperplasia and endometrial carcinoma is more common