Plasma uric acid levels and renal function in Type 2 Diabetes Mellitus

Abstract

Objective: This study investigates the correlation between plasma uric acid levels and renal function in Type 2 Diabetes Mellitus (T2DM) patients. Elevated uric acid levels have been associated with diabetic complications, particularly renal damage.

Methods: A total of 160 participants, including 80 T2DM (Group D) patients and 80 normal controls (Group N), were examined. Plasma levels of glucose, creatinine, urea, electrolytes, and uric acid were measured. Renal function was assessed using estimated glomerular filtration rate (eGFR). The study categorized T2DM patients based on sex, age, and eGFR stages.

Results: T2DM patients exhibited significantly higher plasma uric acid levels compared to controls (p<0.001). eGFR found to be significantly lesser in T2DM patients compared to controls (P<0.05). Gender-based comparisons revealed lesser eGFR levels in females.

Conclusion: Plasma uric acid levels are elevated in T2DM patients. Uric acid may serve as a marker for renal damage in T2DM, highlighting its role in diabetic nephropathy progression.