Resveratrol and Vitamin E ameliorate Carbendazim-induced toxicity in Wistar rats

Abstract

Carbendazim [methyl-2-benzimidazole carbamate, MBC (CBZ)], a metabolite of benomyl, is one of the most widespread environmental contaminants of major concern to human and animal health. The protective effect of resveratrol (RSV), vitamin E (E) and a combination of both on carbendazim-induced toxicity was investigated using haematology, serum biochemistry and histopathology in male Wistar rats. Exposure to Carbendazim (CBZ) caused a significant reduction in the values of PCV and significantly increased WBC as well as platelets counts when compared to the control and other groups while treatment with each of and a combination of RSV and E ameliorated the condition. Also, exposure to CBZ resulted in a significant increase in the values of Urea, Creat, AST, ALT, GGT, Total Cholesterol, Triglycerides and Low Density Lipoproteins while it decreased HDL across the groups. However, RSV and or E ameliorated the condition. Histopathology revealed that CBZ exposure resulted in inflammation of the glomerular apparatus as well as focal areas of granulation and hepatic lesions including fatty degeneration, peri-portal inflammation, cytoplasmic vacuolation and karyorrhexis of hepatocytes in the kidney and liver, respectively. Co-treated with E, RSV or their combination improved the conditions in the kidney and liver. The study demonstrates the ameliorating effects of RSV, E as well as their combination on CBZ-induced toxicities

Keywords: Carbendazim, resveratrol, vitamin E, kidney, liver