BRCA1 and BRCA2 gene mutations in breast cancer among west African women

Abstract

There is an increase in the prevalence of cancer in Africa, while cancer was previously related to the industrialized countries. In fact, until today studies are scanty in all the African regions to find out more about the reality of the disease. However, in West Africa, there are few reports on the genetic factors of breast cancer. Our review was able to establish that very few studies have described the mutations of the BRCA1 / 2 genes in Africa. The dearth of scientific data in West Africa has impacted negatively on prevention, sensitization and management of breast cancer. We strongly suggest studies in general cancer registries of these countries and particularly on the genetic etiology of breast cancer

Keywords: Breast cancer- Genetic risks- BRCA1/2- West Africa