Formation of toxic nitrosamine as a complication of prostatic hyperplasma associated with urinary tract infection and urinary retention

Abstract

The formation of urinary dimethylinitrosamine [DMN] in male patients with benign prostatic hyperplasia [BPH] associated with urinary Tract infection [UTI] was investigated in patients presenting with Klebsiella species infected bladder secondary to [UR]. Specimens from the patients were analysed qualitatively and quantitatively for DMN while blood samples from the same patients were investigated for the activities of common liver enzymes such as alanine transaminase [ALT] and alkaline phosphatase [ALP]. Blood analysis for bilirubin, albumin, total protein content and for creatinine were also carried out. The results obtained in the infected subjects (when compared with those of a healthy group) showed significant mean values of DMN, ALP, AST as 0.12± 0.09mgNO₂/L; 36 ± 1.7iu/L; 7i.u/L respectively (P < 0.05). The values obtained for bilirubin, albumin, total protein, creatinine and ALT were not significantly different from those of control subjects.

Keywords: Dimethylnitrosamine, Hepatotoxicity, , Klebsiella species Urinary, tract infection, Urinary retention.