Effect of crude garlic extract on nicotine induced hyperglycaemia and hyperlipidemia in rats

Abstract

The effect of curde garlic extract on nicotine induced hyperglycaemia and hyperlipidaemia has been studied in albino rats. Four groups of 6 rats each were used. A control group received saline, a second group received 1mg/kg nicotine i.p., the third group received 305 per kg body weight o acqueous garlic extract orally and the fourth group, nicotine + garlic (i.p). These were sacrified 24 hours after last treatment. Serum cholesterol, glucose and triglycerides were assayed by standrd procedures. Garlic treated rats had lower serum cholesterol, triglyceride and glucose levels. The Nicotine + garlic combination also decreased the levels o these parameters but less than the garlic group. Nicotine group had higher levels of the parameters but less than the garlic group. Nicotine group had higher levels of the parameters. Effects of garlic alone and garlic + nicotine was significant (P<0.050. The results show that garlic reduces nicotine-induced hyperglyceamia and hyperlipidaemia in rats.

L’extrait d’ail cru sur L’hypoglycemie et l’ hyperlipidemie cause par la nicotine a ete etudie chez les rats albinos. quatre (4) groups desix (6) rats chacun etaient utilises. un groupe de controle recevait une soluton de sel, un deuxieme (2^e) groupe recevait 1 mg/kg de nicotine, le troisieme (3^e) recevait..... par kg de poids corporel d’ ail dillue administre oralement et le quatrieme (4^e-), de la nicotine qlus du l’ ail. ils etaient (tues) 24 Heures apres le dernien traitement le serum, du cholesterole, glucose et tuglyceudes etaient preleves par les methods standards. Les rats traite’s au l’ail avaient les plus bas taux de cholesterole, triglycerides et glucose. La combinaison de nicotine plus l’aile reduisait aussi le niveau de ces pasametres mais moins que dans le groupe administr’e a’ l’ail. Le groupe administre a la nicotine avait les taux plus eleves mais moins que ceux du l’aile. Le effects de l’ail seul et de l’ail plus nicotine etait significatifs (P<0.05). Les resultats montrent que l’ail reduit l’ hyperglycemie et l’hyperlipidemic cause par la nicotine chez les rats.