Influence of Thyroxine on Blood Parameters and Liver Enzymes in Adult Male and Female Rats

Abstract

This study investigated and compared the influence of exogenous thyroxine with restricted feeding and sex on the blood parameters and liver enzymes in adult male and female Wistar rats. Twelve adult wistar rats (six males and females) were given thyroxine in drinking water at dosage of 50mg/100ml of water/pair/day with restricted pellet feed of 16gm/pair/day for 28 days. Another set of twelve adult Wistars (six males and six females) received 100ml of water/pair/day for 28 days. The control group of twelve adult rats (six females and six males) received feed and water ad-labitum for the same period of 28days. Thyroxine with restricted feeding significantly increased (P< 0.05) haemoglobin level, the alanine aminotransferase values as well as pyruvate aminotransferase values in Wistar rats of both sexes while it significantly reduced the values of white blood cells in both sexes of wistar rats and has no significant effect on values of blood glucose of both sexes. Restricted feeding without thyroxine treatment significantly decreased the values of haemoglobin, white blood cells and red blood cells in wistar rats of both sexes while it significantly increased the levels of alanine aminotrasferase and pyruvate aminotransferase (P<0.05). The results suggest that exogenous thyroxine with restricted feed has significant effects (P <0.05) on blood parameters and liver enzymes in wistar rats of both sexes.

Key-words: Exogenous thyroxine, restricted feed, Wistar rat, blood parameters, Liver enzymes.