Susceptibility of imipenem-resistant Pseudomonas aeruginosa to flavonoid glycosides of date palm (Phoenix dactylifera L.) tamar growing in Al Madinah, Saudi Arabia

Abstract

The fruits of the date palm (Phoenix dactylifera L.) are consumed throughout the world and are an important part of the diet in the Middle East. Dates at tamar stage contain a wide array of flavones, but little is known about the antimicrobial of flavonoid glycosides compounds in dates. In this study, we evaluated the antimicrobial of flavonoid glycosides extracted from the date fruits grown in Al Madinah, Saudi Arabia at full ripe stage against imipenem-resistant P. aeruginosa (IRP). A chloroform fraction prepared from the date showed potent inhibitory activity against IRP. The active compounds were elucidated to be quercetin, luteolin, and apigenin based on their spectral analysis. Flavonoid glycosides showed significant antibacterial activities against IRP. These compounds represent novel leads, and future studies may allow the development of a pharmacologically acceptable antimicrobial agent or class of agents.

Key words: Phoenix dactylifer, flavonoid glycosides, imipenem-resistant P. aeruginosa.