Synthesis and biological activities of substituted N'- benzoylhydrazone derivatives

Abstract

The present study describes the synthesis, antioxidant and antibacterial activities of substituted N'- benzoylhydrazone derivatives, to investigate activities in relation to their SAR. Compounds have been characterised by melting points, MS, ¹H NMR and IR spectra. Antioxidant activities were evaluated using hydroxyl radical (OH) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assays and the IC₅₀ values ranged from 0.68 to 23.66 mg/L and from 0.13 to 22.87 mg/L, respectively. Antibacterial activities of these derivatives were examined by a microdilution method. Compounds 4j and 4q possess significant antibacterial properties on Gram-positive bacteria based on the MIC. Our results indicate that some of these derivatives possess promising antioxidant and antibacterial activities, which can be explored for generating new leads of potential drug candidates.

Key words: Acylhydrazone derivatives, antioxidant activity, antibacterial activity, SAR.