Effects of recombinant human nerve growth factor on cervical cancer

Abstract

Nerve growth factor (NGF) plays a crucial role in the life of the sympathetic and sensory nervous systems. However, the roles of NGF to cervical cancer remain deeply unknown. This study investigated the effect of recombinant human nerve growth factor (rhNGF) on cervical cancer. It was found that the proliferation of hela cells was inhibited by rhNGF and there were some apoptotic-like cell deaths. After tumor modeling of mice implanted U14 cells, it was shown that the growth of tumor tissues was inhibited in response to rhNGF and the concentration of virus been rhNGF was not more than 1.0×10⁷ pfu/ml. In addition, the immune abilities of thymus and spleen were improved by rhNGF. Finally, it was shown that SOD level of tumor tissues was improved under the right concentration of rhNGF. Therefore, the mentioned result showed that cervical cancer is probably treated by rhNGF, which is depended on the concentration of rhNGF.

Key words: rhNGF, cervical cancer, tumor inhibition.