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Association between circulating levels of P-selectins and burden of thrombus formation in patients with STelevation acute myocardial infarction
Abstract
high-sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), soluble intercellular cell adhesion molecule-1 (sICAM-1), PS and white blood cell (WBC) count were collected before PCI. The WBC count, neutrophil granulocyte count and PS level were significantly higher in the HBTF group than in the LBTF group (11.24 ± 3.62 vs 10.00 ± 3.35, p = 0.014; 8.84 ± 3.42 vs 7.66 ± 3.23, p = 0.015; 13.62 ± 8.13 vs 7.80 ± 4.17, p = 0.000, respectively). Patients in the HBTF group had a significantly lower prevalence of post-PCI thrombolysis in myocardial infarction (TIMI) grade-3 flow than that of the LBTF group (84.52% vs 93.69%, p = 0.037). Compared with the LBTF group, the HBTF group had higher peak values of the myocardial band (MB) fraction of creatine kinase (CK-MB). (308.52 ± 215.26 vs 213.79 ± 185.27, p = 0.005). By logistic regression analysis, PS (OR 1.259, 95%CI 1.125 - 1.408, p = 0.000) were independent predictors of thrombus formation. PS level was the strongest independent predictor of angiographic morphologic features that indicate HBTF in AMI.