Parasiticidal, antifungal and antibacterial activities of Onosma griffithii Vatke

Abstract

Onosma griffithii was screened for possible pharmacological activities. The crude methanolic extract (MeOH) and its fractions demonstrated parasiticidal activity (IC 50 (ìg/ml ± S.D) = 31.03 ± 0.23) against Leishmania major. Based on the IC 50 values, the potency of the standard drug (Pentamidine) and test fractions were of the order as: Pentamidine > crude extract > n-hexane fraction > ethyl acetate (ETOAc) fraction > chloroform fraction (CHCl3) fraction > n-butanol (BUOH) fraction > aqueous fraction. Similarly
moderate antifungal activity was displayed by the crude methanolic extract against Aspergillus flavus and Fusarium solani. Against the Staphylococcus aureus, the aqueous fraction demonstrated moderate antibacterial activity.