In vitro cytotoxicity of crude alkaloidal extracts of South African Menispermaceae against three cancer cell linese

Abstract

The cytotoxicity of crude alkaloid extracts obtained from the leaves and rhizomes of all the South African members of the family Menispermaceae (seven genera and 13 species) was tested against MCF7 (breast), UACC62 (melanoma) and TK10 (renal) cancer cell lines. Extracts of ten of the thirteen species showed positive activity against all three cancer cell lines with significant inhibition of cellular growth at TGI (total growth inhibition) values lower than 6.25

g/ml for Albertisia delagoensis and Antizoma angustifolia leaves.