Association of ribosomal anti-P antibodies with different parameters of lupus

Abstract

Systemic Lupus Erythematosus is an autoimmune multisystem disorder with protean manifestations and variable behavior. The main objectives of this study are to verify the association of ribosomal anti-P
antibodies with neuropsychiatric lupus manifestations and to find out the relationship of ribosomal anti-P antibodies with other autoimmune parameters of lupus. Ribosomal anti-P antibodies were evaluated in the serum of 41 systemic lupus erythematosus (SLE) patients as well as ANA, dsDNA, anti- Sm, anti-SSA, anti-SSB, anti-histone by an indirect ELISA technique. Apart from Immunological tests, we also studied hematological parameters and biochemical parameters. Of the 41 SLE patients, ribosomal anti-P antibodies were significantly elevated in the sera of 6 lupus patients suffering from severe depression, anxiety, headache and lupus psychosis. Immunological parameters like ANA,
dsDNA were positive in 100% of the Anti-Rib-P positive patients; but 66.6% were positive for SSA, only 33.3% for Sm, and none of them were positive for anti-histone and SSB. Biochemical parameters like
urea, creatinine were higher than the normal range in 66.6% of the anti-P positive lupus patients, suggestive of lupus nephritis.