Application of an antibacterial dressing spray in the prevention of post-operative infection in oral cancer patients: A phase 1 clinical trial

Abstract

This study investigates the effects on the prevention of oral infection after operation in oral region by using an antibacterial dressing spray (JUC spray). 60 patients diagnosed with grade 1 and 2 of oral
squamous cell cancinoma, and the conservation surgery had applied to them under general anesthesia. Half of these patients were treated with JUC and the rest accepted traditional method. The complete
blood picture (CBP) and the growth of bacteria in the wound were analyzed. The average wound healing time in JUC group was significantly shorter than that in the control group. The amount of bacteria presented in wound was lower in JUC group than that in the traditional group. There was no significant difference between the CBP of the two groups. The JUC antibacterial dressing spray, after spraying on the surface of the wound formed a layer of physically antibacterial molecular film to prevent the growth of bacteria and effectively reduced the average wound healing time.