In vitro assessment of antibacterial activity of bark extracts of Khaya senegalensis

Abstract

In vitro antibacterial activity of aqueous, ethanol and acetone extracts of Khaya senegalensis were tested against Staphylococcus aureus, Streptococcus pyogenes, Salmonella typhi, Shigella dysenteriae, Klebsiella pneumoniae and Pseudomonas aeruginosa isolated from clinical specimen. The acetone extracts showed higher antibacterial activity compared to the aqueous and ethanol extracts. The minimum inhibitory concentration of acetone extracts was in the range of 6.5 to 12.5 mg/ml while
the minimum bactericidal concentration ranges between 6.5 to 25.0 mg/ml. The antibacterial activity of the extracts was not significantly affected by heating at 100o C for 1 h but the activity was lost at pH 8.0.