Antibacterial activity and cytotoxicity of essential oil of Lantana Camara L. leaves from Nigeria

Abstract

The chemical composition of essential oil obtained from air-dried leaves of Lantana camara L. by hydrodistillation was analyzed by GC and GC-MS. A total of thirty-two compounds representing 74.8% of the oil were identified. The main constituents were 1,8-cineol (15.8%), sabinene (14.7%) and β- caryophylene (8.9%). The essential oil was tested for antibacterial activity against 6 strains, using disc diffusion method, and for cytotoxicity using brine-shrimp lethality assay. The oil showed moderate activity against Candida albican, Bacillus subtilis, Staphylococcus typhi, Pseudomonas aeruginosa and Bacillus aureus. These activities support its potential use as a remedy for bacterial infectious diseases. The essential oil with LC50 value of 0.01 was found to be highly toxic.