Influence of fixed-oils in the dispersion of some water-insoluble antimicrobial compounds

Abstract

Ampicillin trihydrate, salicylic acid and griseofulvin were subjected to interphasal partitioning between an organic and aqueous phases formed from mixtures of sterile fixed-oils and distilled water. The fixed-oils used were groundnut oil, cotton-seed oil, vegetable oil and cod-liver oil. At each of the varying concentrations of the respective antimicrobial compounds, more molecules of each compound were found to have partitioned into organic (oily) phase than the aqueous phase. Based on physico-chemical and susceptibility studies report with Staphylococcus aureus, groundnut oil and cod-liver oil ranked better than cotton-seed oil and vegetable oil oils in their dispersion ability of the drugs. The results support the use of the local fixed-oils as suitable dispersion media in pharmaceutical oil-based preparations and susceptibility testing.

African Journal of Biotechnology Vol. 4 (6), pp. 502-505, 2005