Antiproliferative activity of some novel platinum complexes on C6 glioma and MCF-7 breast cancer cells

Abstract

The anti-cancer chemotherapeutic potential of novel platinum(II) complexes of salicylate derivatives [Pt(dppe)(SA)₂, Pt(dppm)(SA)₂] and fumaric acid [Pt(dppe)(FU)₂] were determined, using two cancer cell lines, breast cancer (MCF-7) and glioma cells (C6). IC₅₀ values of the three compounds were lower in the cisplatin-resistant cell type C6 cell lines than in MCF-7 cells.

Key words: Cisplatin, antiproliferative activity, breast cancer cells (MCF-7), glioma cells (C6), IC₅₀.