Mechanism of ciprofloxacin resistance in Shigella dysenteriae

Abstract

Bacterial resistance to quinolones has emerged rapidly and such resistance has traditionally been attributed to the chromosomally mediated mechanisms that alter the quinolone targets and/or overproduce multidrug resistance efflux pumps. In the present investigation possible mechanism of ciprofloxacin (Cp) resistance in Shigella dysenteriae was studied. While the growth of sensitive S. dysenteriae was completely inhibited at 1 μg /ml concentration of ciprofloxacin, the resistant strain tolerated even 10 μg /ml concentration of ciprofloxacin. Mechanism of resistance was found to be the presence of plasmid.

Keywords: Ciprofloxacin, Shigella dysenteriae, quinolone, plasmid, Resistance, SDS.

African Journal of Biotechnology Vol. 12(41), pp. 6025-6031