Effects of ethanol extract of Cissus quadrangularis on induced gastric ulcer in rats

Abstract

Antiulcer activities of the ethanol extract of Cissus quadrangularis roots on indomethacin and ethanolinduced gastric ulcers were investigated. The results obtained show that the ulceration in gastric linings of the stomach of rats pre-treated with the C. quadrangularis extract before induction with ethanol and indomethacin decreased significantly when compared to the control. The protective effect of the extract increased in a dose-dependent manner in both ulcer models. There were significant decreases (p <0.05) in the number of ulcer lesions when rats were administered with the graded doses of the extract and ranitidine (100 mg/kg body weights) compared with the control groups in both models. Results from this study suggest that the extract of C, quadrangularis roots possesses antiulcer activities.

Keywords: Cissus quadrangularis, ranitidine, indomethacin, ethanol and ulcer lesions.