Evaluation of the wound healing activity of Cinnamomum zeylanicum extract on experimentally induced wounds in rats

Abstract

The present study was undertaken to determine the effect of Cinnamomum zeylanicum on experimentally induced excision wounds in rats. Thirty-two rats were divided into four groups of eight rats each. Group A received a placebo containing 0.75% cinnamon, Group B received a placebo containing 1.5% cinnamon, Group C as a control group did not receive any treatment, and finally, Group D received blank placebo; Groups C and D were considered as one group (standard). The results were taken on days 3, 7, 14 and 21 and a histological evaluation was carried out on the samples. The result shows that cinnamon extract had a significant (p<0.05, **p<0.01) effect on wound healing; it accelerated the healing process of the wounds. Significant enclosure rates were seen after 7 days of study. The present study proved that C. zeylanicum was effective in treating experimentally induced wounds and hasten healing, showing a dose-dependent treatment trend. It especially increased epithelialization in treatment groups compared to other groups.

Key words: Cinnamomum zeylanicum, induced excision, epithelialization, wound healing.