Preliminary in vitro cytotoxic assay of human liver carcinoma cells (HepG2) of organotin(IV) complexes: Synthesis and characterization of organotin(IV) complexes of 2,4-dinitrobenzoic and 3,5-dinitrobenzoic acids

Abstract

A total of five organotin(IV) carboxylate complexes was successfully synthesized and characterized quantitatively and qualitatively. Results of the infrared spectroscopy of the parent acids and complexes showed that the coordination took place via oxygen atoms from the carboxylate group. From the preliminary in vitro cytotoxic assay study, triorganotin(IV) complexes (2 and 5) were found to exhibit better activity as compared to diorganotin(IV) complexes (1, 3 and 4) but lower activity as compared to the reference drug. In addition, within the diorganotin(IV) complexes, monomeric type (3) exhibited a slightly better activity as compared to the organodistannoxane dimer types (1 and 4).

Keywords: Preliminary in vitro cytotoxic assay, organotin(IV) complexes, comparison study