The effects of dietary supplementation of tomato peel ultrafine powder on glycemic response in streptozotocin-induced diabetic rats and blood lipids in high-fat diet rats

Abstract

This study was designed to investigate the effects of dietary supplementation of tomato peel ultrafine powder (TPUP) on glycemic response in streptozotocin (STZ)-induced diabetic rats and blood lipids in high-fat diet rats. STZ-induced diabetic rats and high-fat diet rats were administrated orally with TPUP for 21 and 49 days and subjected to biochemical analysis of blood glucose and lipids profiles, respectively. Compared with diabetic control rats, STZ-induced diabetic rats treated with TPUP for 3 weeks had significantly (P<0.05) increased level of body weight and decreased levels of fasting blood glucose, insulin and C-peptide by 39.9, 51 and 17.1% in high dose (1.0 g kg^-1bw) group and 32.8, 38.8 and 22.9% in low dose (0.2 g kg^-1bw) group, respectively. Besides a dramatically decrease (P<0.05) in total cholesterol level up to 32.6% obtained in high dose (1.0 g kg^-1bw) group, no significant changes were observed with triglycerides, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels with TPUP treated high-fat diet rats, as compared to those index of high-fat diet control rats. These findings suggest that TPUP might be fabricated as an additive of functional foods because of its potential antihyperglycemic and hypolipidemic effects in STZ-induced diabetic rats and high-fat diet rats.

Keywords: Tomato pomace, tomato peel ultrafine powder, STZ-induced diabetic rats, hypoglycemic effect, hypolipidemic effect

African Journal of Biotechnology Vol. 12(6), pp. 580-587