Characterization and in vitro studies on anticancer activity of exopolymer of Bacillus thuringiensis S13

Abstract

The objective of the present work was to isolate and characterize the exopolymer producer from a marine environment. The exopolymer producing strain (S13) was identified as Bacillus thuringiensis S13. Characterization of exopolymer shows the presence of brominated compound responsible for cytotoxicity on lung cancer cell line (A549) on XTT assay. An in vitro study of bacterial exopolymer shows the presence of cytotoxic effects on cell lines. Further, active compound in exopolymer responsible for cytotoxicity has to be characterized. The exopolymer produced by B. thuringiensis S13, showed potent cytotoxic effects, and could be used as therapy in cancer after further studies.

Keywords: Bacillus thuringiensis S13, exopolymer, IR, GCMS analysis and lung cancer cell line.

African Journal of Biotechnology, Vol 13(21) 2137-2144