Novel lipid-based dermal microgels of Neobacin®

Abstract

This study investigates the potential of novel microgles based on solid lipid microparticles (SLMs) as a sustained delivery system for neobacin^®, a topical antibiotic drug powder. Matrices generated from sunseed oil and goat fat (1:9, 2:8 and 3:7) was surface-modified with Phospholipon^® 90G and employed to formulate SLM-based microgels. The microgels were characterized in terms of in vivo wound healing in rats, in vitro permeation, membrane drug retention studies and antimicrobial activity against various microorganisms using standard cup-plate agar diffusion method. The 3:7 microgels exhibited sustained release property, achieving 34% drug permeation over 12 h, 64% membrane drug retention and largest growth inhibition zone diameters (IZD) on all organisms, whereas commercial neobacin^® gel achieved 35% drug permeation at 4 h and 72% membrane drug retention. In vivo wound healing followed this order 3:7>1:9>2:8 better than neobacin^® powder. Neobacin^® microgel formulation despite rapid degradation possessed greater wound healing and antimicrobial property than the conventional powder form of neobacin^®.
 
Key words: Microgels, surface-modified solid lipid microparticles, sustained release, neobacin^®.