Phytochemical screening and antimicrobial activities of the leaf extract of Entandrophragama angolense

Abstract

The phytochemical screening and antimicrobial activities of the leaf extract of Entandrophragma angolense were investigated using the agar well diffusion method. The methanolic extracts at crude level were shown in vitro to inhibit Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and Streptococcus cremoris with diameter zones of inhibition ranging from 6 to 14 mm. Minimum inhibitory concentration was 3.13 and 6.25 mg/ml for Gram positive and negative bacterial strains, respectively. Minimum bactericidal concentration (MBC) was 6.25 and 12.5 mg/ml for Gram positive and negative bacterial strains, respectively. The leaf extract also had bioactive compounds such as tannins, alkaloids, saponin and cardiac glycoside which may be responsible for the biological properties of this plant. The study confirms the antibacterial potential of E. angolense.

Key words: Entandrophragma angolense, antimcrobial activity, phytocheamical.