Antimicrobial susceptibility assessment of compound from Aspergillus fumigatus

Abstract

Ethyl acetate extract of the culture filtrate of Aspergillus fumigatus on chromatographic analysis has led to the isolation of the compound, AF-1 which exhibited a significant in vitro antimicrobial activity against the tested pathogenic microorganism. The structure of the isolated compound, AF-1 was identified as 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one from its IR, UV, EI-MS, ¹³C-NMR, ¹H-NMR, HMBC and HMQC data. This is the first report of the compound, AF-1 from the A. fumigatus.

Key words: Aspergillus, 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one, antimicrobial screening, bioactive compound.