Influence of percutaneous coronary intervention (PCI) on plasma B-type natriuretic peptide in patients with acute ST elevated myocardial infarction

Abstract

B-type natriuretic peptide (BNP) is secreted from the ventricles in response to volume expansion and pressure overload. It is related to the injuries and function of the heart. This study aimed to investigate whether emergency percutaneous coronary intervention (PCI) could influence the BNP level in patients with ST-segment elevation myocardial infarction (STEMI). 193 patients admitted with STEMI were enrolled in this study. The BNP levels were measured at admission. All patients underwent routine clinical laboratory tests in the first day of hospitalization. 92 patients underwent emergency PCI, and 101 patients underwent drug conservative treatment. The patients that underwent PCI were divided into two subgroups depending on reperfusion time (0 to 3 h, n=42; 3 to 6 h, n=50) for analysis. The study reveals BNP levels were significantly lower in patients undergoing emergency PCI when compared with the conservative treatment (261.0±410.9pg/ml versus 921.5±1126.7pg/ml, p<0.01). BNP levels were significantly lower in super-acute PCI patients than in acute PCI paitents. BNP levels were higher in patients whose blood flow was not TIMI 3. BNP is positively related to CKMB. Earlier reperfusion in infarct-related artery results in significantly better BNP level and may be good for myocardial salvage and preservation of heart function.

Key words: B-type natriuretic peptide, ST-segment elevation myocardial infarction, emergency percutaneous coronary intervention.