Potential predictive factors of positive prostate biopsy in the Chinese population

Abstract

There are numerous arguments for the predictive factors of positive prostate biopsies differing according to race and region. This retrospective study aimed to determine predictive factors for a positive prostate biopsy in Chinese men. Data were collected from 1608 men who underwent a prostate biopsy for suspected prostate cancer. Variables analyzed included age, prostate specific antigen (PSA) level, prostate volume and PSA density (PSAD). Logistic regression analysis estimated relative risk, 95% confidence intervals and p values. Overall, 598 (37.19%) of the 1608 biopsied had prostate cancer. Independent predictors of a positive biopsy result include advanced age, elevated PSA levels, small prostate volume and increased PSAD. Our study showed significant predictors for positive prostate biopsy in Chinese men and a combination of age, PSA, prostate volume and PSAD better defined the probability of a positive biopsy than any factor alone. In the future, we may be able to use our finding to create a nomogram for predicting positive prostate biopsy in Chinese men.

Key words: Prostate biopsy, PSA, prostate volume, prostatic neoplasms