Amlodipine besylate impairs the morphology of bone marrow in adult male wistar rats

Abstract

Amlodipine is a long-acting calcium channel blocker used in the treatment of hypertension and angina. In adult man, the treatment regimen is 5 or 10 mg daily. This study evaluated the effects of prolonged oral administration of Amlodipine Besylate on the morphology of bone marrow in adult male Wistar rats. Sixteen rats (140 - 190 g) comprising of four groups were employed in the study. Rats of Control Group I received physiological saline orally while rats of Experimental Groups II - IV received oral administrations of 5, 10 and 15 mg/kg bodyweight of Amlodipine Besylate respectively for nine weeks. Histo-pathological examinations of the bone marrow showed normal cytoarchitecture of erythrocytes and leukocytes in rats of Control Group I. However, dose-dependent degeneration and lyses of erythrocytes and leukocytes were observed in amlodipine-treated rats. In conclusion, impaired morphology of the bone marrow were observed in amlodipine-treated adult male Wistar rats

Key words: Amlodipine Besylate, bone marrow, morphology, rats.