Effects of chronic administration of aqueous alchornea cordifolia leaf on the kidney of adult wistar rats

Abstract

Effects of chronic administration of aqueous extract of alchornea cordifolia leaf commonly used in the treatment of diarrhoea, cough, gonorrhoea, chest pain and anemia on the kidney of adult wistar rats was investigated. Rats of both sexes (n=20), with an average weight of 200g were randomly assigned into test (n=10) and control (n=10) groups. Rats in the test group were given the aqueous extract of alchornea cordifolia leaf at a single dose of 250mg/kg body weight daily for thirty days through the orogastric tube administration while the control group received equal volume of distilled water through the same route and for the same period. Rats were fed with grower’s mash obtained from Edo Feeds and Flour Mill Limited, Ewu, Edo state, Nigeria. Rats were sacrificed by cervical dislocation method on the thirty-first day of the experiment and the kidney was carefully dissected out, dried, weighed, and quickly fixed in 10% formal saline for further routine histological study. Findings indicated that the kidney in the test group (group B) showed some level of distortion and disruption of the cytoarchitecture of the renal cortical structure with marked diffuse glomerulonephritis and an enlarged Bowman’s space as compared to the control group. Findings also indicated that there was a significant (P < 0.05) decrease in weights (g) of the test kidney as compared to the control group. Chronic administration of aqueous extract of alchornea cordifolia leaf may therefore have an adverse effect on the kidney of adult wistar rats. It is recommended that further studies aimed at corroborating these observations be carried out.

Keywords: Morphology effects, Alchornea cordifolia, Kidney, Wistar rats.