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Main Article Content
Synthesis, characterization and biological activities of substituted cinnoline culphonamides
Abstract
Background: The Cinnoline moiety and Sulphonamide moiety both have good antimicrobial properties. Methods: In the present study both the moieties were condensed to synthesize substituted cinnoline sulphonamide derivatives using intramolecular cyclization followed by diazotization in order to get synergistic activity. Results: These derivatives particularly halogen substituted cinnoline derivatives showed potent antimicrobial activity. Conclusion: Further investigations are required to find out possible mechanism of action.
Keywords: Cinnoline, Antibacterial, Antifungal
