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Jan 11, 2025Keywords:
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Main Article Content
The effect of radio-frequency ablation in treating pulmonary ground glass nodule patients and its influence on pulmonary function
Abstract
Background: With widespread application of low-dose thin-section chest CT screening, the detection rate of patients with subsolid nodules (SNs) as CT findings has increased remarkably.
Objective: To clarify effect of radio-frequency ablation (RFA) in treating pulmonary ground glass nodule (GGN) patients and its impact on pulmonary function.
Methods: A total of 100 patients diagnosed with pulmonary GGN in our hospital from January 2019 to December 2021 by pulmonary thin-section CT + enhanced imaging examination and all underwent simultaneous needle biopsy were enrolled and randomly divided into control group and observation group, with 50 cases each. The control group received treatment with traditional surgery. The observation group received treatment with RFA. The surgical indicators, surgical treatment efficacy, levels of inflammatory cytokines, complications and pulmonary function indicators were assessed between two groups.
Results: The operation time, hospital stay and intraoperative blood loss in observation group were markedly shorter/less than controls (P < 0.05). No residual recurrence was observed in total 84 nodules of 50 cases in observation group. The size of nodules was observed by CT 1, 3 and 6 months after operation. With prolongation of postoperative time, nodules gradually shrank, and after 6 months, fibrous cord scar residue gradually formed, with statistical significance relative to those before operation (P < 0.05). The postoperative IL-6, CRP and TNF-α in both groups presented elevation, whereas postoperative changes in IL-6, CRP and TNF-α in observation group presented depletion relative to control group, with statistical significance (P < 0.05). The complication rate in observation group presented depletion relative to control group, with statistical significance (P < 0.05). The FVC, FEV1, FEV1%, MVV and PEF in both groups presented depletion 1 month after operation and presented statistical significance relative to those before operation except for FEV1% (P < 0.05), and changes in observation group presented depletion relative to control group. Six months after operation, FVC, FEV1, FEV1%, MVV and PEF in both groups had recovered to preoperative levels and presented no difference relative to preoperative level (P > 0.05), and presented no difference between two groups (P > 0.05).
Conclusion: RFA for the therapy of pulmonary GGN is safe and effective, without surgical scar, and is less traumatic to the body, which has a good application prospect.
Keywords: Radio-frequency ablation; pulmonary ground glass nodule; pulmonary function; inflammatory cytokines.
